Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts

doi:10.1016/j.cjche.2021.06.015

中国化学工程学报 ›› 2021, Vol. 39 ›› Issue (11): 297-305.DOI: 10.1016/j.cjche.2021.06.015

• Material and Product Engineering • 上一篇下一篇

Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts

Tingting Yang, Han Xu, Congrui Zhao, Di Tang, Fan Mu, Hongjiang Lu, Zhoufeng Rao, Shufang Wang

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China

收稿日期:2021-03-30 修回日期:2021-06-21 出版日期:2021-11-28 发布日期:2021-12-27
通讯作者: Shufang Wang
基金资助:
This work was supported by National Natural Science Foundation of China (31870966, 81800931, 81901062), National Key Research Development Program of China (2020YFA0803701, 2017YFC1103504), and Tianjin Science Foundation (20YFZCSY01020).

Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts

Tingting Yang, Han Xu, Congrui Zhao, Di Tang, Fan Mu, Hongjiang Lu, Zhoufeng Rao, Shufang Wang

State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin 300071, China

Received:2021-03-30 Revised:2021-06-21 Online:2021-11-28 Published:2021-12-27
Contact: Shufang Wang
Supported by:
This work was supported by National Natural Science Foundation of China (31870966, 81800931, 81901062), National Key Research Development Program of China (2020YFA0803701, 2017YFC1103504), and Tianjin Science Foundation (20YFZCSY01020).

摘要/Abstract

摘要： In this study, a series of poly (butylene succinate) (PBSU)/gelatin composites were prepared by electrospinning. The morphology, physicochemical analysis, biomechanical properties, biocompatibility, and biodegradability of the materials were evaluated. The results showed that the ultimate tensile stress of the vascular PBSU/gelatin grafts at (95/5), (90/10), (85/15), and (80/20) was (4.17±0.54) MPa, (3.81±0.44) MPa, 2.94±0.69 MPa and 2.11±0.72 MPa respectively, and the burst pressure was (282.7±22.3) kPa, (295.3±3.9) kPa, (306.8±13.9) kPa and (307.6±9.0) kPa respectively, which met the requirements of tissue-engineered blood vessels. Furthermore, the addition of gelatin improved the hydrophilicity and degradation properties of PBSU, thus enhancing cell adhesion and promoting the inward growth of vascular smooth muscle cells. In summary, the research in this paper provides a useful reference for the preparation and optimization of vascular scaffolds.

关键词: Poly (butylene succinate), Gelatin, Co-electrospinning, Degradation, Vascular graft

Abstract: In this study, a series of poly (butylene succinate) (PBSU)/gelatin composites were prepared by electrospinning. The morphology, physicochemical analysis, biomechanical properties, biocompatibility, and biodegradability of the materials were evaluated. The results showed that the ultimate tensile stress of the vascular PBSU/gelatin grafts at (95/5), (90/10), (85/15), and (80/20) was (4.17±0.54) MPa, (3.81±0.44) MPa, 2.94±0.69 MPa and 2.11±0.72 MPa respectively, and the burst pressure was (282.7±22.3) kPa, (295.3±3.9) kPa, (306.8±13.9) kPa and (307.6±9.0) kPa respectively, which met the requirements of tissue-engineered blood vessels. Furthermore, the addition of gelatin improved the hydrophilicity and degradation properties of PBSU, thus enhancing cell adhesion and promoting the inward growth of vascular smooth muscle cells. In summary, the research in this paper provides a useful reference for the preparation and optimization of vascular scaffolds.

Key words: Poly (butylene succinate), Gelatin, Co-electrospinning, Degradation, Vascular graft

Tingting Yang, Han Xu, Congrui Zhao, Di Tang, Fan Mu, Hongjiang Lu, Zhoufeng Rao, Shufang Wang. Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts[J]. 中国化学工程学报, 2021, 39(11): 297-305.

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Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts

Construction and evaluation of co-electrospun poly (butylene succinate)/gelatin materials as potential vascular grafts

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