SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2023, Vol. 62 ›› Issue (10): 21-30.DOI: 10.1016/j.cjche.2023.04.012

• Full Length Article • 上一篇    下一篇

Volumetricand ultrasonic properties of thiamine hydrochloride drug in aqueous solutions of choline-based deep eutectic solvents at different temperatures

Hemayat Shekaari, Fariba Ghaffari, Masumeh Mokhtarpour   

  1. Department of Physical Chemistry, University of Tabriz, Tabriz, Iran
  • 收稿日期:2022-10-19 修回日期:2023-04-04 出版日期:2023-10-28 发布日期:2023-12-23
  • 通讯作者: Hemayat Shekaari,E-mail:hemayatt@yahoo.com
  • 基金资助:
    The authors wish to thank financial support from the graduate council of the University of Tabriz, Tabriz, Iran.

Volumetricand ultrasonic properties of thiamine hydrochloride drug in aqueous solutions of choline-based deep eutectic solvents at different temperatures

Hemayat Shekaari, Fariba Ghaffari, Masumeh Mokhtarpour   

  1. Department of Physical Chemistry, University of Tabriz, Tabriz, Iran
  • Received:2022-10-19 Revised:2023-04-04 Online:2023-10-28 Published:2023-12-23
  • Contact: Hemayat Shekaari,E-mail:hemayatt@yahoo.com
  • Supported by:
    The authors wish to thank financial support from the graduate council of the University of Tabriz, Tabriz, Iran.

摘要: Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The optimal design of such processes requires a molecular-level understanding of the interactions between drug molecules and biological membranes. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs + co-solvents in aqueous media is the central issue in many types of research because they exert their impact by interacting with biological membranes. This work is aimed to measure the density and speed of sound for the thiamine hydrochloride in water + deep eutectic solvents (DESs) mixtures (choline chloride/urea, choline chloride/ethylene glycol and choline chloride/glycerol) at temperature range (293.15–308.15) K. By correlation of the evaluated parameters in some standard relations, the partial molar parameters i.e. apparent molar volumes, Vφ,m, and apparent molar isentropic compression, ks,φ,m, are calculated. In addition, apparent molar isobaric expansion, Eφ,m0, and Hepler’s constant are computed from the density and speed of sound data. For fitting the experimental Vφ,m and ks,φ,m the Redlich-Meyer equation was employed that the important quantities; standard partial molar volume, Vm0, and partial molar isentropic compression, ks,m0, were obtained. The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.

关键词: Deep eutectic solvents, Thiamine hydrochloride, Density, Speed of sound, Redlich-Meyer equation

Abstract: Important efforts have been made over the past years to improve the drug acts, which leads to the discovery of novel drug preparations and delivery systems. The optimal design of such processes requires a molecular-level understanding of the interactions between drug molecules and biological membranes. The thermodynamic investigation provides deep and complete knowledge of interactions and the choice of appropriate and suitable production compounds in pharmaceutical fields. Particularly, the analysis of drugs + co-solvents in aqueous media is the central issue in many types of research because they exert their impact by interacting with biological membranes. This work is aimed to measure the density and speed of sound for the thiamine hydrochloride in water + deep eutectic solvents (DESs) mixtures (choline chloride/urea, choline chloride/ethylene glycol and choline chloride/glycerol) at temperature range (293.15–308.15) K. By correlation of the evaluated parameters in some standard relations, the partial molar parameters i.e. apparent molar volumes, Vφ,m, and apparent molar isentropic compression, ks,φ,m, are calculated. In addition, apparent molar isobaric expansion, Eφ,m0, and Hepler’s constant are computed from the density and speed of sound data. For fitting the experimental Vφ,m and ks,φ,m the Redlich-Meyer equation was employed that the important quantities; standard partial molar volume, Vm0, and partial molar isentropic compression, ks,m0, were obtained. The thermodynamic analysis of the studied system also plays a crucial role in the pharmaceutical industry.

Key words: Deep eutectic solvents, Thiamine hydrochloride, Density, Speed of sound, Redlich-Meyer equation