SCI和EI收录∣中国化工学会会刊

›› 2008, Vol. 16 ›› Issue (3): 451-455.

• • 上一篇    下一篇

Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers

赵原壁, 邱祖民, 黄佳英   

  1. School of Environmental Science and Engineering, Nanchang University, Nanchang 330031, China
  • 收稿日期:2007-09-10 修回日期:2008-04-30 出版日期:2008-06-28 发布日期:2008-06-28
  • 通讯作者: QIU Zumin,E-mail:mzqiu@ncu.edu.cn
  • 基金资助:
    Technology Project of Jiangxi Provincial Education Department;Jiangxi Provincial Science Department

Preparation and Analysis of Fe3O4 Magnetic Nanoparticles Used as Targeted-drug Carriers

ZHAO Yuanbi, QIU Zumin, HUANG Jiaying   

  1. School of Environmental Science and Engineering, Nanchang University, Nanchang 330031, China
  • Received:2007-09-10 Revised:2008-04-30 Online:2008-06-28 Published:2008-06-28
  • Supported by:
    Technology Project of Jiangxi Provincial Education Department;Jiangxi Provincial Science Department

摘要: Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3·6H2O and FeCl2·4H2O with addition of ammonium hydroxide.The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized,and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope(TEM),dynamic laser scattering analyzer(DLS)and X-ray diffraction(XRD). The results revealed that the magnetic nanoparticles were cubic shaped and dispersive,with narrow size distribution and average diameter of 11.4 nm.It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution.The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully.A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets.In conclusion,the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carriers of targeted-drug in future application.

关键词: targeted-drug, Fe3O4, magnetic particle, nanometre

Abstract: Fe3O4 magnetic nanoparticles were prepared by the aqueous co-precipitation of FeCl3·6H2O and FeCl2·4H2O with addition of ammonium hydroxide.The conditions for the preparation of Fe3O4 magnetic nanoparticles were optimized,and Fe3O4 magnetic nanoparticles obtained were characterized systematically by means of transmission electron microscope(TEM),dynamic laser scattering analyzer(DLS)and X-ray diffraction(XRD). The results revealed that the magnetic nanoparticles were cubic shaped and dispersive,with narrow size distribution and average diameter of 11.4 nm.It was found that the homogeneous variation of pH value in the solution via the control on the dropping rate of aqueous ammonia played a critical role in size distribution.The magnetic response of the product in the magnetic field was also analyzed and evaluated carefully.A 32.6 mT magnetic field which is produced by four ferromagnets was found to be sufficient to excite the dipole moments of 0.05 g Fe3O4 powder 2 cm far away from the ferromagnets.In conclusion,the Fe3O4 magnetic nanoparticles with excellent properties were competent for the magnetic carriers of targeted-drug in future application.

Key words: targeted-drug, Fe3O4, magnetic particle, nanometre