SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2021, Vol. 38 ›› Issue (10): 30-42.DOI: 10.1016/j.cjche.2021.03.013

• Reviews • 上一篇    下一篇

Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications

Shaobo Wang1,2, Yunchao Zhao1,2, Zeyu Zhang1,2, Yalong Zhang1,2, Linlin Li1,2,3   

  1. 1. School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, Guangxi University, Nanning 530004, China;
    2. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China;
    3. School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
  • 收稿日期:2021-02-19 修回日期:2021-03-19 出版日期:2021-10-28 发布日期:2021-12-02
  • 通讯作者: Linlin Li
  • 基金资助:
    The work was supported by the National Natural Science Foundation of China (82072065, 81471784), the National Key Research and Development Program of the Minister of Science and Technology, China (2016YFA0202703), and the National Youth Talent Support Program.

Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications

Shaobo Wang1,2, Yunchao Zhao1,2, Zeyu Zhang1,2, Yalong Zhang1,2, Linlin Li1,2,3   

  1. 1. School of Chemistry and Chemical Engineering, Center on Nanoenergy Research, Guangxi University, Nanning 530004, China;
    2. Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 100083, China;
    3. School of Nanoscience and Technology, University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2021-02-19 Revised:2021-03-19 Online:2021-10-28 Published:2021-12-02
  • Contact: Linlin Li
  • Supported by:
    The work was supported by the National Natural Science Foundation of China (82072065, 81471784), the National Key Research and Development Program of the Minister of Science and Technology, China (2016YFA0202703), and the National Youth Talent Support Program.

摘要: Metal and amino acid (AA), as two kinds of entities, have been widely involved in biomaterials and nanomedicines. Recently, the marriage of them has developed new nanoformulations, amino acid-metal coordinated nanomaterials (AMCNs), which show great biomedical application potential in cancer therapy, antibacterial applications, biomedical imaging, etc. With the respective characteristics of metal and AA with rich biological and chemical properties, AMCNs can not only act as drug carriers with specific tumor targeting ability, but also realize synergistic therapy and imaging-guided therapy. Although the design and synthesis of amino acid-metal coordinated nanomaterials have been in-depth investigated, there are few systematic reviews on their biomedical application. In this review, we give a comprehensive summary of recent progresses in the design, fabrication, and biomedical applications of AMCNs. We also propose the future outlooks and challenges in aforementioned field. We expect that this review would contribute some inspiration for future research and development for amino acid metal coordinated nanomaterials.

关键词: Amino acids, Metal, Coordination chemistry, Cancer therapy, Antibacterial applications, Imaging

Abstract: Metal and amino acid (AA), as two kinds of entities, have been widely involved in biomaterials and nanomedicines. Recently, the marriage of them has developed new nanoformulations, amino acid-metal coordinated nanomaterials (AMCNs), which show great biomedical application potential in cancer therapy, antibacterial applications, biomedical imaging, etc. With the respective characteristics of metal and AA with rich biological and chemical properties, AMCNs can not only act as drug carriers with specific tumor targeting ability, but also realize synergistic therapy and imaging-guided therapy. Although the design and synthesis of amino acid-metal coordinated nanomaterials have been in-depth investigated, there are few systematic reviews on their biomedical application. In this review, we give a comprehensive summary of recent progresses in the design, fabrication, and biomedical applications of AMCNs. We also propose the future outlooks and challenges in aforementioned field. We expect that this review would contribute some inspiration for future research and development for amino acid metal coordinated nanomaterials.

Key words: Amino acids, Metal, Coordination chemistry, Cancer therapy, Antibacterial applications, Imaging