SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2024, Vol. 72 ›› Issue (8): 19-25.DOI: 10.1016/j.cjche.2024.05.010

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Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

Yao Pei1, Ran Wang1, Xiang Rong1, Xiang Xia2, Hexiang Wang1, Zongwei Zhang1, Tian Qiu1, Saran Long1,2, Jianjun Du1,2, Jiangli Fan1,2, Wen Sun1,2, Xiaojun Peng1   

  1. 1 State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
    2 Ningbo Institute of Dalian University of Technology, Ningbo 315016, China
  • 收稿日期:2024-02-26 修回日期:2024-05-11 出版日期:2024-08-28 发布日期:2024-10-17
  • 通讯作者: Wen Sun,E-mail:sunwen@dlut.edu.cn
  • 基金资助:
    This work was financially supported by the National Natural Science Foundation of China (22078046), Fundamental Research Fundamental Funds for the Central Universities (DUT22LAB601), Liaoning Binhai Laboratory (LBLB-2023-03), and China Postdoctoral Science Foundation (2023M740487).

Isoindigo nanoparticles for photoacoustic imaging-guided tumor photothermal therapy

Yao Pei1, Ran Wang1, Xiang Rong1, Xiang Xia2, Hexiang Wang1, Zongwei Zhang1, Tian Qiu1, Saran Long1,2, Jianjun Du1,2, Jiangli Fan1,2, Wen Sun1,2, Xiaojun Peng1   

  1. 1 State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Dalian University of Technology, Dalian 116024, China;
    2 Ningbo Institute of Dalian University of Technology, Ningbo 315016, China
  • Received:2024-02-26 Revised:2024-05-11 Online:2024-08-28 Published:2024-10-17
  • Contact: Wen Sun,E-mail:sunwen@dlut.edu.cn
  • Supported by:
    This work was financially supported by the National Natural Science Foundation of China (22078046), Fundamental Research Fundamental Funds for the Central Universities (DUT22LAB601), Liaoning Binhai Laboratory (LBLB-2023-03), and China Postdoctoral Science Foundation (2023M740487).

摘要: The key factor in photothermal therapy lies in the selection of photothermal agents. Traditional photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency. Herein, we have designed and synthesized an isoindigo (IID) dye. We used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors. In order to improve the photothermal stability and tumor targeting ability, we encapsulated IID into nanoparticles. As a result, the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency (67%) upon 635 nm laser irradiation. Thus, the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

关键词: Photothermal therapy, Isoindigo, Nanoparticles, Photoacoustic imaging

Abstract: The key factor in photothermal therapy lies in the selection of photothermal agents. Traditional photothermal agents generally have problems such as poor photothermal stability and low photothermal conversion efficiency. Herein, we have designed and synthesized an isoindigo (IID) dye. We used isoindigo as the molecular center and introduced common triphenylamine and methoxy groups as rotors. In order to improve the photothermal stability and tumor targeting ability, we encapsulated IID into nanoparticles. As a result, the nanoparticles exhibited high photothermal stability and photothermal conversion efficiency (67%) upon 635 nm laser irradiation. Thus, the nanoparticles demonstrated a significant inhibitory effect on live tumors in photothermal therapy guided by photoacoustic imaging and provided a viable strategy to overcome the treatment challenges.

Key words: Photothermal therapy, Isoindigo, Nanoparticles, Photoacoustic imaging