SCI和EI收录∣中国化工学会会刊

›› 2017, Vol. 25 ›› Issue (6): 732-740.DOI: 10.1016/j.cjche.2016.09.014

• Fluid Dynamics and Transport Phenomena • 上一篇    下一篇

Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production

Xiaoqiang Jia1,2,3, Lin Qi1, Yaguang Zhang1, Xue Yang1, Hongna Wang1, Fanglong Zhao1, Wenyu Lu1,2,3   

  1. 1. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
    2. Key Laboratory of Systems Bioengineering(Tianjin University), Ministry of Education, Tianjin 300072, China;
    3. Synthetic Biology Platform, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin 300072, China
  • 收稿日期:2016-05-04 修回日期:2016-09-30 出版日期:2017-06-28 发布日期:2017-08-02
  • 通讯作者: Wenyu Lu,E-mail address:wenyulu@tju.edu.cn
  • 基金资助:
    Supported by the National Key Basic Research Program of China (No.2014CB745100), National Natural Science Foundation of China (No.21576197), Tianjin Research Program of Application Foundation and Advanced Technology (No.14JCQNJC06700), Technological Research and Development Programs of the China Offshore Environmental Services Ltd. (CY-HB-10-ZC-055).

Computational fluid dynamics simulation of a novel bioreactor for sophorolipid production

Xiaoqiang Jia1,2,3, Lin Qi1, Yaguang Zhang1, Xue Yang1, Hongna Wang1, Fanglong Zhao1, Wenyu Lu1,2,3   

  1. 1. Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China;
    2. Key Laboratory of Systems Bioengineering(Tianjin University), Ministry of Education, Tianjin 300072, China;
    3. Synthetic Biology Platform, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin 300072, China
  • Received:2016-05-04 Revised:2016-09-30 Online:2017-06-28 Published:2017-08-02
  • Supported by:
    Supported by the National Key Basic Research Program of China (No.2014CB745100), National Natural Science Foundation of China (No.21576197), Tianjin Research Program of Application Foundation and Advanced Technology (No.14JCQNJC06700), Technological Research and Development Programs of the China Offshore Environmental Services Ltd. (CY-HB-10-ZC-055).

摘要: This paper describes three-dimensional computational fluid dynamics (CFD) simulations of gas-liquid flow in a novel laboratory-scale bioreactor contained dual ventilation-pipe and double sieve-plate bioreactor (DVDSB) used for sophorolipid (SL) production.To evaluate the role of hydrodynamics in reactor design,the comparisons between conventional fed-batch fermenter and DVDSB on the hydrodynamic behavior are predicted by the CFD methods.Important hydrodynamic parameters of the gas-liquid two-phase system such as the liquid phase velocity field,turbulent kinetic energy and volume-averaged overall and time-averaged local gas holdups were simulated and analyzed in detail.The numerical results were also validated by experimental measurements of overall gas holdups.The yield of sophorolipids was significantly improved to 484 g·L-1 with a 320 h fermentation period in the new reactor.

关键词: Bioreactors, Gas hold-up, Computational fluid dynamics(CFD), Hydrodynamics, Sophorolipid production

Abstract: This paper describes three-dimensional computational fluid dynamics (CFD) simulations of gas-liquid flow in a novel laboratory-scale bioreactor contained dual ventilation-pipe and double sieve-plate bioreactor (DVDSB) used for sophorolipid (SL) production.To evaluate the role of hydrodynamics in reactor design,the comparisons between conventional fed-batch fermenter and DVDSB on the hydrodynamic behavior are predicted by the CFD methods.Important hydrodynamic parameters of the gas-liquid two-phase system such as the liquid phase velocity field,turbulent kinetic energy and volume-averaged overall and time-averaged local gas holdups were simulated and analyzed in detail.The numerical results were also validated by experimental measurements of overall gas holdups.The yield of sophorolipids was significantly improved to 484 g·L-1 with a 320 h fermentation period in the new reactor.

Key words: Bioreactors, Gas hold-up, Computational fluid dynamics(CFD), Hydrodynamics, Sophorolipid production