Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

doi:10.1016/j.cjche.2022.10.009

中国化学工程学报 ›› 2023, Vol. 58 ›› Issue (6): 170-178.DOI: 10.1016/j.cjche.2022.10.009

• Full Length Article • 上一篇下一篇

Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

Pengcheng Zou, Kai Wang

The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

收稿日期:2022-09-04 修回日期:2022-10-18 出版日期:2023-06-28 发布日期:2023-08-31
通讯作者: Kai Wang,E-mail:kaiwang@tsinghua.edu.cn
基金资助:
We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21991104) and the Shandong Province Major Science and Technology Innovation Project (2019JZZY020401).

Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

Pengcheng Zou, Kai Wang

The State Key Lab of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

Received:2022-09-04 Revised:2022-10-18 Online:2023-06-28 Published:2023-08-31
Contact: Kai Wang,E-mail:kaiwang@tsinghua.edu.cn
Supported by:
We gratefully acknowledge the financial support from the National Natural Science Foundation of China (21991104) and the Shandong Province Major Science and Technology Innovation Project (2019JZZY020401).

摘要/Abstract

摘要： The methanolysis of amides, which is widely employed in the synthetic organic chemistry, hardly occurs under mild conditions. To safely and controllably intensify the methanolysis reaction with high-temperature and high-pressure environment, a continuous tubular reaction technology is developed, whose space-time yield is over twice of that of the conventional batch reaction. The methanolysis of acetanilide is selected as the representative reaction, and the influences of temperature, pressure, reactant and catalyst concentration, and residence time on the reaction performances are systematically investigated. Taking the advantages of precise temperature and reaction time control by the tubular reactor, the kinetics of acetanilide methanolysis are determined and compared to the kinetics of acetanilide hydrolysis reaction. The tubular reaction method is also employed to test a variety of other amides to show the effects of substituents, steric hindrance, and alkalinity on the reaction rate of methanolysis.

关键词: Amide methanolysis reaction, Flow chemistry, Continuous reaction, Process intensification

Abstract: The methanolysis of amides, which is widely employed in the synthetic organic chemistry, hardly occurs under mild conditions. To safely and controllably intensify the methanolysis reaction with high-temperature and high-pressure environment, a continuous tubular reaction technology is developed, whose space-time yield is over twice of that of the conventional batch reaction. The methanolysis of acetanilide is selected as the representative reaction, and the influences of temperature, pressure, reactant and catalyst concentration, and residence time on the reaction performances are systematically investigated. Taking the advantages of precise temperature and reaction time control by the tubular reactor, the kinetics of acetanilide methanolysis are determined and compared to the kinetics of acetanilide hydrolysis reaction. The tubular reaction method is also employed to test a variety of other amides to show the effects of substituents, steric hindrance, and alkalinity on the reaction rate of methanolysis.

Key words: Amide methanolysis reaction, Flow chemistry, Continuous reaction, Process intensification

Pengcheng Zou, Kai Wang. Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor[J]. 中国化学工程学报, 2023, 58(6): 170-178.

Pengcheng Zou, Kai Wang. Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor[J]. Chinese Journal of Chemical Engineering, 2023, 58(6): 170-178.

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Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

Methanolysis of amides under high-temperature and high-pressure conditions with a continuous tubular reactor

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