Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling

doi:10.1016/j.cjche.2024.05.020

中国化学工程学报 ›› 2024, Vol. 72 ›› Issue (8): 164-176.DOI: 10.1016/j.cjche.2024.05.020

Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling

Zhenguang Liu¹, Zexiang Ding¹, Yifeng Cao^1,2, Baojian Liu^1,2, Qiwei Yang^1,2, Zhiguo Zhang^1,2, Qilong Ren^1,2, Zongbi Bao^1,2

1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China;
2 Institute of Zhejiang University-Quzhou, Quzhou 324000, China

收稿日期:2024-04-07 修回日期:2024-05-03 出版日期:2024-08-28 发布日期:2024-10-17
通讯作者: Yifeng Cao,E-mail:caoyf@zju.edu.cn;Zongbi Bao,E-mail:baozb@zju.edu.cn
基金资助:
This work was supported by the National Key Research and Development Program of China (2021YFC2103800), the National Natural Science Foundation of China (U21A20301), and the Research Funds of Institute of Zhejiang University-Quzhou (IZQ2022RCZX004 and IZQ2021RCZX015).

Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling

Zhenguang Liu¹, Zexiang Ding¹, Yifeng Cao^1,2, Baojian Liu^1,2, Qiwei Yang^1,2, Zhiguo Zhang^1,2, Qilong Ren^1,2, Zongbi Bao^1,2

1 Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China;
2 Institute of Zhejiang University-Quzhou, Quzhou 324000, China

Received:2024-04-07 Revised:2024-05-03 Online:2024-08-28 Published:2024-10-17
Contact: Yifeng Cao,E-mail:caoyf@zju.edu.cn;Zongbi Bao,E-mail:baozb@zju.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China (2021YFC2103800), the National Natural Science Foundation of China (U21A20301), and the Research Funds of Institute of Zhejiang University-Quzhou (IZQ2022RCZX004 and IZQ2021RCZX015).

摘要/Abstract

摘要： The equilibrium solubility of Rebaudioside A (Reb A) Form II in binary mixtures of methanol/ethanol and ethyl acetate was quantitatively determined within the temperature range of 283.15-328.15 K at ambient pressure. The experimental findings indicate a positive correlation between the solubility of Reb A (Form II) and both the temperature and the methanol/ethanol content in the solvent system. To describe the solubility data, six distinct models were employed: the modified Apelblat equation, the λh model, the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model, the van't Hoff-Jouyban-Acree (VJA) model, the Apelblat-Jouyban-Acree (AJA) model, and the non-random two-liquid (NRTL) model. The combined nearly ideal binary solvent/Redlich-Kister model exhibited the most precise fit for solubility in methanol + ethyl acetate mixtures, reflected by an average relative deviation (ARD) of 0.0011 and a root mean square deviation (RMSD) of 12×10^-7. Conversely, for ethanol + ethyl acetate mixtures, the modified Apelblat equation provided a superior correlation (ARD = 0.0014, RMSD = 4×10^-7). Furthermore, thermodynamic parameters associated with the dissolution of Reb A (Form II), including enthalpy, entropy, and the Gibbs energy change, were inferred from the data. The findings underscore that the dissolution process is predominantly endothermic across the solvent systems examined. Notably, the entropy changes appear to have a significant influence on the Gibbs free energy associated with the dissolution of Reb A (Form II), suggesting that entropic factors may play a pivotal role in the studied systems.

关键词: Rebaudioside A, Solubility, Thermodynamic modeling, Dissolution, Binary solvent

Abstract: The equilibrium solubility of Rebaudioside A (Reb A) Form II in binary mixtures of methanol/ethanol and ethyl acetate was quantitatively determined within the temperature range of 283.15-328.15 K at ambient pressure. The experimental findings indicate a positive correlation between the solubility of Reb A (Form II) and both the temperature and the methanol/ethanol content in the solvent system. To describe the solubility data, six distinct models were employed: the modified Apelblat equation, the λh model, the combined nearly ideal binary solvent/Redlich-Kister (CNIBS/R-K) model, the van't Hoff-Jouyban-Acree (VJA) model, the Apelblat-Jouyban-Acree (AJA) model, and the non-random two-liquid (NRTL) model. The combined nearly ideal binary solvent/Redlich-Kister model exhibited the most precise fit for solubility in methanol + ethyl acetate mixtures, reflected by an average relative deviation (ARD) of 0.0011 and a root mean square deviation (RMSD) of 12×10^-7. Conversely, for ethanol + ethyl acetate mixtures, the modified Apelblat equation provided a superior correlation (ARD = 0.0014, RMSD = 4×10^-7). Furthermore, thermodynamic parameters associated with the dissolution of Reb A (Form II), including enthalpy, entropy, and the Gibbs energy change, were inferred from the data. The findings underscore that the dissolution process is predominantly endothermic across the solvent systems examined. Notably, the entropy changes appear to have a significant influence on the Gibbs free energy associated with the dissolution of Reb A (Form II), suggesting that entropic factors may play a pivotal role in the studied systems.

Key words: Rebaudioside A, Solubility, Thermodynamic modeling, Dissolution, Binary solvent

Zhenguang Liu, Zexiang Ding, Yifeng Cao, Baojian Liu, Qiwei Yang, Zhiguo Zhang, Qilong Ren, Zongbi Bao. Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling[J]. 中国化学工程学报, 2024, 72(8): 164-176.

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Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling

Temperature-dependent solubility of Rebaudioside A in methanol/ethanol and ethyl acetate mixtures: Experimental measurements and thermodynamic modeling

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