SCI和EI收录∣中国化工学会会刊

中国化学工程学报 ›› 2023, Vol. 62 ›› Issue (10): 159-167.DOI: 10.1016/j.cjche.2023.03.012

• Full Length Article • 上一篇    下一篇

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Yi Wu1, Hongzhou Shang2, Shisheng Lai3, Yali Di4, Xiaoran Sun1, Ning Qiao2, Lihua Han1, Zheng Zhao1, Yujin Lu2   

  1. 1. College of Chemical Engineering, North China University of Science and Technology, Tangshan 063210, China;
    2. College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China;
    3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China;
    4. Department of Cardiology, Tangshan Central Hospital, Tangshan 063000, China
  • 收稿日期:2022-11-23 修回日期:2023-03-01 出版日期:2023-10-28 发布日期:2023-12-23
  • 通讯作者: Hongzhou Shang,E-mail:zhouzhou198213@163.com

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Yi Wu1, Hongzhou Shang2, Shisheng Lai3, Yali Di4, Xiaoran Sun1, Ning Qiao2, Lihua Han1, Zheng Zhao1, Yujin Lu2   

  1. 1. College of Chemical Engineering, North China University of Science and Technology, Tangshan 063210, China;
    2. College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China;
    3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China;
    4. Department of Cardiology, Tangshan Central Hospital, Tangshan 063000, China
  • Received:2022-11-23 Revised:2023-03-01 Online:2023-10-28 Published:2023-12-23
  • Contact: Hongzhou Shang,E-mail:zhouzhou198213@163.com

摘要: A novel light responsive nanosphere was constructed, and it was used as a drug carrier to investigate the loading and release properties of the Quercetin (QU). In this paper, mesoporous silica nanoparticles (MSN) were used as a substrate, and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce —NH2, and the azobenzene-4,4'-dicarboxylic acid (AZO) was used as light responsive agent to introduce the group of —N = N—, and then β-cyclodextrin (β-CD) was combined with AZO through host–guest interaction to construct light responsive nanoparticles (MSN@β-CD). The structure and properties of the carrier were analyzed by FTIR, BET, XPS, TGA, XRD, SEM and TEM. In vitro drug release studies showed the release rate of QU@MSN@β-CD (dark) was 12.19% within 72 h, but the release rate of QU@MSN@β-CD (light 10 min) was 26.09%, exhibiting a light-responsive property. The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU. Therefore, the controllable light-responsive drug delivery system has great application prospects.

关键词: Silica, Drug delivery system, Light-responsive, β-CD, Nanomaterials, Support

Abstract: A novel light responsive nanosphere was constructed, and it was used as a drug carrier to investigate the loading and release properties of the Quercetin (QU). In this paper, mesoporous silica nanoparticles (MSN) were used as a substrate, and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce —NH2, and the azobenzene-4,4'-dicarboxylic acid (AZO) was used as light responsive agent to introduce the group of —N = N—, and then β-cyclodextrin (β-CD) was combined with AZO through host–guest interaction to construct light responsive nanoparticles (MSN@β-CD). The structure and properties of the carrier were analyzed by FTIR, BET, XPS, TGA, XRD, SEM and TEM. In vitro drug release studies showed the release rate of QU@MSN@β-CD (dark) was 12.19% within 72 h, but the release rate of QU@MSN@β-CD (light 10 min) was 26.09%, exhibiting a light-responsive property. The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU. Therefore, the controllable light-responsive drug delivery system has great application prospects.

Key words: Silica, Drug delivery system, Light-responsive, β-CD, Nanomaterials, Support