Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

doi:10.1016/j.cjche.2023.03.012

中国化学工程学报 ›› 2023, Vol. 62 ›› Issue (10): 159-167.DOI: 10.1016/j.cjche.2023.03.012

• Full Length Article • 上一篇下一篇

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Yi Wu¹, Hongzhou Shang², Shisheng Lai³, Yali Di⁴, Xiaoran Sun¹, Ning Qiao², Lihua Han¹, Zheng Zhao¹, Yujin Lu²

1. College of Chemical Engineering, North China University of Science and Technology, Tangshan 063210, China;
2. College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China;
3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China;
4. Department of Cardiology, Tangshan Central Hospital, Tangshan 063000, China

收稿日期:2022-11-23 修回日期:2023-03-01 出版日期:2023-10-28 发布日期:2023-12-23
通讯作者: Hongzhou Shang,E-mail:zhouzhou198213@163.com

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Yi Wu¹, Hongzhou Shang², Shisheng Lai³, Yali Di⁴, Xiaoran Sun¹, Ning Qiao², Lihua Han¹, Zheng Zhao¹, Yujin Lu²

1. College of Chemical Engineering, North China University of Science and Technology, Tangshan 063210, China;
2. College of Materials Science and Engineering, North China University of Science and Technology, Tangshan 063210, China;
3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China;
4. Department of Cardiology, Tangshan Central Hospital, Tangshan 063000, China

Received:2022-11-23 Revised:2023-03-01 Online:2023-10-28 Published:2023-12-23
Contact: Hongzhou Shang,E-mail:zhouzhou198213@163.com

摘要/Abstract

摘要： A novel light responsive nanosphere was constructed, and it was used as a drug carrier to investigate the loading and release properties of the Quercetin (QU). In this paper, mesoporous silica nanoparticles (MSN) were used as a substrate, and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce —NH₂, and the azobenzene-4,4'-dicarboxylic acid (AZO) was used as light responsive agent to introduce the group of —N = N—, and then β-cyclodextrin (β-CD) was combined with AZO through host–guest interaction to construct light responsive nanoparticles (MSN@β-CD). The structure and properties of the carrier were analyzed by FTIR, BET, XPS, TGA, XRD, SEM and TEM. In vitro drug release studies showed the release rate of QU@MSN@β-CD (dark) was 12.19% within 72 h, but the release rate of QU@MSN@β-CD (light 10 min) was 26.09%, exhibiting a light-responsive property. The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU. Therefore, the controllable light-responsive drug delivery system has great application prospects.

关键词: Silica, Drug delivery system, Light-responsive, β-CD, Nanomaterials, Support

Abstract: A novel light responsive nanosphere was constructed, and it was used as a drug carrier to investigate the loading and release properties of the Quercetin (QU). In this paper, mesoporous silica nanoparticles (MSN) were used as a substrate, and 3-aminopropyl triethyoxysilane was used as a surface modification agent to introduce —NH₂, and the azobenzene-4,4'-dicarboxylic acid (AZO) was used as light responsive agent to introduce the group of —N = N—, and then β-cyclodextrin (β-CD) was combined with AZO through host–guest interaction to construct light responsive nanoparticles (MSN@β-CD). The structure and properties of the carrier were analyzed by FTIR, BET, XPS, TGA, XRD, SEM and TEM. In vitro drug release studies showed the release rate of QU@MSN@β-CD (dark) was 12.19% within 72 h, but the release rate of QU@MSN@β-CD (light 10 min) was 26.09%, exhibiting a light-responsive property. The CCK8 tests demonstrated that MSN@β-CD could significantly decrease the toxicity of QU. Therefore, the controllable light-responsive drug delivery system has great application prospects.

Key words: Silica, Drug delivery system, Light-responsive, β-CD, Nanomaterials, Support

Yi Wu, Hongzhou Shang, Shisheng Lai, Yali Di, Xiaoran Sun, Ning Qiao, Lihua Han, Zheng Zhao, Yujin Lu. Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica[J]. 中国化学工程学报, 2023, 62(10): 159-167.

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Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

Preparation and evaluation of controllable drug delivery system: A light responsive nanosphere based on β-cyclodextrin/mesoporous silica

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