Current advances of biocontainment strategy in synthetic biology

doi:10.1016/j.cjche.2022.07.019

中国化学工程学报 ›› 2023, Vol. 56 ›› Issue (4): 141-151.DOI: 10.1016/j.cjche.2022.07.019

Current advances of biocontainment strategy in synthetic biology

Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

收稿日期:2022-03-22 修回日期:2022-07-19 出版日期:2023-04-28 发布日期:2023-06-13
通讯作者: Bin Jia,E-mail:bin.jia@tju.edu.cn
基金资助:
This research was supported by grants from the National Key Research and Development Program of China (2019YFA0903800), and the National Natural Science Foundation of China (31800719 and 21621004).

Current advances of biocontainment strategy in synthetic biology

Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan

Frontier Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China

Received:2022-03-22 Revised:2022-07-19 Online:2023-04-28 Published:2023-06-13
Contact: Bin Jia,E-mail:bin.jia@tju.edu.cn
Supported by:
This research was supported by grants from the National Key Research and Development Program of China (2019YFA0903800), and the National Natural Science Foundation of China (31800719 and 21621004).

摘要/Abstract

摘要： Synthetic biotechnology has led to the widespread application of genetically modified organisms (GMOs) in biochemistry, bioenergy, and therapy. However, the uncontrolled spread of GMOs may lead to genetic contamination by horizontal gene transfer, resulting in unpredictable biosafety risks. To deal with these challenges, many effective methods have been developed for biocontainment. In this article, we summarize and discuss recent advances in biocontainment strategies from three aspects: DNA replication, transcriptional regulation, and protein translation. We also briefly introduce the efforts in the biocontainment convention, such as the recent publication of the Tianjin Biosecurity Guidelines for the Code of Conduct for Scientists.

关键词: Genetically modified organisms (GMOs), Biocontainment, Biosecurity, Synthetic biology, Molecular biology, Biotechnology

Abstract: Synthetic biotechnology has led to the widespread application of genetically modified organisms (GMOs) in biochemistry, bioenergy, and therapy. However, the uncontrolled spread of GMOs may lead to genetic contamination by horizontal gene transfer, resulting in unpredictable biosafety risks. To deal with these challenges, many effective methods have been developed for biocontainment. In this article, we summarize and discuss recent advances in biocontainment strategies from three aspects: DNA replication, transcriptional regulation, and protein translation. We also briefly introduce the efforts in the biocontainment convention, such as the recent publication of the Tianjin Biosecurity Guidelines for the Code of Conduct for Scientists.

Key words: Genetically modified organisms (GMOs), Biocontainment, Biosecurity, Synthetic biology, Molecular biology, Biotechnology

Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan. Current advances of biocontainment strategy in synthetic biology[J]. 中国化学工程学报, 2023, 56(4): 141-151.

Xueying Zhu, Zhaoyang Zhang, Bin Jia, Yingjin Yuan. Current advances of biocontainment strategy in synthetic biology[J]. Chinese Journal of Chemical Engineering, 2023, 56(4): 141-151.

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Current advances of biocontainment strategy in synthetic biology

Current advances of biocontainment strategy in synthetic biology

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