Recent advances in the biosynthesis of natural products from C1 compounds

doi:10.1016/j.cjche.2025.03.013

中国化学工程学报 ›› 2025, Vol. 83 ›› Issue (7): 277-285.DOI: 10.1016/j.cjche.2025.03.013

Recent advances in the biosynthesis of natural products from C1 compounds

Xinzhe Zhang, Aipeng Li, Xiaohan Huang, Qiang Fei

School of Chemical Engineering and Technology, Xi'an Key Laboratory of C1 Compound Bioconversion Technology, Xi'an Jiaotong University, Xi'an 710049, China

收稿日期:2025-01-05 修回日期:2025-03-16 接受日期:2025-03-24 出版日期:2025-07-28 发布日期:2025-07-28
通讯作者: Qiang Fei,E-mail:feiqiang@xjtu.edu.cn
基金资助:
This work was supported by the Science Fund for Distinguished Young Scholars of Shaanxi Province (2022JC-09), the China Postdoctoral Science Foundation (2023M732780), the Higher Education Institution Academic Discipline Innovation and Talent Introduction Plan (B23025), and the Youth Innovation Team of Shaanxi Universities.

Recent advances in the biosynthesis of natural products from C1 compounds

Xinzhe Zhang, Aipeng Li, Xiaohan Huang, Qiang Fei

School of Chemical Engineering and Technology, Xi'an Key Laboratory of C1 Compound Bioconversion Technology, Xi'an Jiaotong University, Xi'an 710049, China

Received:2025-01-05 Revised:2025-03-16 Accepted:2025-03-24 Online:2025-07-28 Published:2025-07-28
Contact: Qiang Fei,E-mail:feiqiang@xjtu.edu.cn
Supported by:
This work was supported by the Science Fund for Distinguished Young Scholars of Shaanxi Province (2022JC-09), the China Postdoctoral Science Foundation (2023M732780), the Higher Education Institution Academic Discipline Innovation and Talent Introduction Plan (B23025), and the Youth Innovation Team of Shaanxi Universities.

摘要/Abstract

摘要： One-carbon (C1) compounds, such as CO₂, methane, and methanol, are emerging as promising feedstocks for next-generation biomanufacturing due to their abundance and low cost. In recent years, there has been growing interest in harnessing microorganisms to convert these carbon sources into valuable natural products (NPs), which offers great potential for sustainable development. This review systematically outlines recent advancements in biocatalysts, synthetic biology, and process optimization aimed at improving the feasibility and scalability of producing C1-based NPs. Current challenges and insights into NPs biomanufacturing from C1 compounds are thoroughly examined in the areas of multi-gene editing, metabolic regulation, and synthetic microbial consortium. With ongoing progress in biosynthetic tools and fermentation techniques, C1-based biomanufacturing is becoming a versatile and sustainable platform for generating diverse value-added products.

关键词: Synthetic biology, One-carbon compounds, Natural products, Biocatalysis, Carbon neutralization, Biotechnology

Abstract: One-carbon (C1) compounds, such as CO₂, methane, and methanol, are emerging as promising feedstocks for next-generation biomanufacturing due to their abundance and low cost. In recent years, there has been growing interest in harnessing microorganisms to convert these carbon sources into valuable natural products (NPs), which offers great potential for sustainable development. This review systematically outlines recent advancements in biocatalysts, synthetic biology, and process optimization aimed at improving the feasibility and scalability of producing C1-based NPs. Current challenges and insights into NPs biomanufacturing from C1 compounds are thoroughly examined in the areas of multi-gene editing, metabolic regulation, and synthetic microbial consortium. With ongoing progress in biosynthetic tools and fermentation techniques, C1-based biomanufacturing is becoming a versatile and sustainable platform for generating diverse value-added products.

Key words: Synthetic biology, One-carbon compounds, Natural products, Biocatalysis, Carbon neutralization, Biotechnology

Xinzhe Zhang, Aipeng Li, Xiaohan Huang, Qiang Fei. Recent advances in the biosynthesis of natural products from C1 compounds[J]. 中国化学工程学报, 2025, 83(7): 277-285.

Xinzhe Zhang, Aipeng Li, Xiaohan Huang, Qiang Fei. Recent advances in the biosynthesis of natural products from C1 compounds[J]. Chinese Journal of Chemical Engineering, 2025, 83(7): 277-285.

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Recent advances in the biosynthesis of natural products from C1 compounds

Recent advances in the biosynthesis of natural products from C1 compounds

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